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Cost-Effectiveness Analysis If tirzepatide produces 50% more weight loss than semaglutide (which clinical trials suggest), the cost per pound lost might actually be similar despite higher absolute cost: Semaglutide at $199: $96 per pound lost (based on trial averages) Tirzepatide at $349: potentially $105 per pound lost if weight loss is proportionally higher The medications are relatively comparable in cost-effectiveness, making the choice based more on individual response than pure cost considerations

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